Acido Mefenamico

Acido Mefenamico: A Deep Dive into the Wonder Drug

Understanding Acido Mefenamico

Acido Mefenamico, commonly known as Mefenamic acid, is a non-steroidal anti-inflammatory drug (NSAID) used to alleviate pain, inflammation, and fever. It belongs to the fenamate class of NSAIDs and is particularly effective in treating menstrual pain and other inflammatory conditions.

Mechanism of Action

Acido Mefenamico works by inhibiting the production of prostaglandins, which are chemicals that promote inflammation and pain. By blocking prostaglandin synthesis, Acido Mefenamico reduces inflammation and alleviates pain.

Pharmacokinetics

* **Absorption:** Acido Mefenamico is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 2-3 hours. * **Distribution:** The drug is widely distributed throughout the body, including synovial fluid and inflamed tissues. * **Metabolism:** Acido Mefenamico is metabolized in the liver and excreted primarily through the kidneys. * **Half-life:** The elimination half-life of Acido Mefenamico is approximately 2 hours.

Indications and Dosage

Acido Mefenamico is indicated for the following conditions: * **Menstrual pain (dysmenorrhea)** * **Rheumatoid arthritis** * **Osteoarthritis** * **Ankylosing spondylitis** * **Acute musculoskeletal pain** The usual dosage of Acido Mefenamico is 500 mg every 6-8 hours, with a maximum daily dose of 1500 mg.

Contraindications and Precautions

Acido Mefenamico is contraindicated in patients with: * **Known hypersensitivity to the drug** * **Active peptic ulcer disease** * **History of gastrointestinal bleeding** * **Severe kidney or liver impairment** Acido Mefenamico should be used with caution in patients with: * **Asthma** * **Heart failure** * **Hypertension** * **History of gastrointestinal disorders**

Adverse Effects

Acido Mefenamico is generally well-tolerated, but common adverse effects include: * **Gastrointestinal upset (nausea, vomiting, diarrhea)** * **Headache** * **Dizziness** * **Skin rash** Rare but serious adverse effects include: * **Gastrointestinal bleeding** * **Hepatic toxicity** * **Kidney failure**

Conclusion

Acido Mefenamico is an effective and widely used NSAID for the management of pain, inflammation, and fever. It is particularly effective in treating menstrual pain and other inflammatory conditions. However, it is important to be aware of its contraindications, precautions, and potential adverse effects before using Acido Mefenamico.